Suggest Entresto for heart failure patients with persistent symptoms

You'll hear about Entresto (en-TRESS-toh), a new drug for symptomatic heart failure with reduced ejection fraction.

It's the first "angiotensin receptor neprilysin inhibitor" (ARNI)...and combines sacubitril (sah-KYOO-bih-tril) with valsartan.

Sacubitril works by inhibiting the enzyme neprilysin. This increases vasodilation and urinary sodium loss...and enhances ARB effects.

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