Watch for Direct Oral Anticoagulant (Pradaxa, etc) Drug Interactions

You'll see drug interaction alerts pop up with the direct oral anticoagulants (DOACs)...Eliquis (apixaban), Pradaxa (dabigatran), and Xarelto (rivaroxaban).

We know interactions are less common with DOACs than warfarin.

But Eliquis and Xarelto are metabolized by CYP3A4...and absorption of all three DOACs is affected by P-glycoprotein.

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