Chloroquine can be used for leg cramps.

Some prescribers are using chloroquine or hydroxychloroquine (Plaquenil, etc) as alternatives to quinine for nighttime leg cramps.

But not because they work better. In fact, there’s not much evidence that they work for leg cramps. But hydroxychloroquine and chloroquine are derived from quinine and work similarly.

Prescribers are using chloroquine 250 mg daily for 2 to 3 weeks, followed by 250 to 500 mg once per week. Hydroxychloroquine is dosed 200 mg daily for two weeks, then once per week.