Is it okay to combine an SSRI (fluoxetine, etc) with an SNRI (Effexor XR, Cymbalta)

Is it okay to combine an SSRI (fluoxetine, etc) with an SNRI (Effexor XR, Cymbalta)?

These are sometimes combined to try to improve the antidepressant effect...or to treat multiple conditions.

For example, a patient may end up on an SSRI for depression plus an SNRI for fibromyalgia or pain.

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