warnings about codeine toxicity, especially in kids

Please see FDA's Aug 2012 safety communication concerning codeine use in certain children

You'll see warnings about codeine toxicity, especially in kids.

Codeine is a prodrug that's not active until it's metabolized to morphine by CYP2D6 enzymes. But 2D6 activity varies.

Up to 10% of Caucasians and up to 30% of some other races are ultrarapid metabolizers. They produce HIGHER morphine levels...increasing their risk of toxicity.

Get concise advice on drug therapy, plus unlimited access to CE

Pharmacist's Letter Canada includes:

  • 12 issues every year, with brief articles about new meds and hot topics
  • 300+ CE courses, including the popular CE-in-the-Letter
  • Quick reference drug comparison charts
  • Access to the entire archive

Already a subscriber? Log in

Volume pricing available. Get quote