Put the Aspirin and NSAID Interaction in Perspective
New data will reignite debate about whether NSAIDs reduce the CV protective effect of aspirin.
We know that NSAIDs may interact with aspirin. This is because aspirin binds to COX-1 to inhibit platelet aggregation...and nonselective NSAIDs can compete for the same receptor.
NSAID labelling even says NSAIDs may decrease aspirin's CV benefit.