Consider It a Red Flag if You See a Direct Oral Anticoagulant Plus Warfarin
Should warfarin ever be COMBINED with a direct oral anticoagulant (DOAC)...Eliquis (apixaban), Xarelto (rivaroxaban), etc?
Rarely. If short-term anticoagulant overlap is needed, an injectable (enoxaparin, etc) is almost always a better choice than a DOAC.
Explain DOACs can raise INR...making it hard to interpret warfarin's effect. Plus two oral anticoagulants is a recipe for mix-ups and harm.