Pinpoint Where PDE5 Inhibitors Fit for Raynaud’s Phenomenon

PDE5 inhibitors (sildenafil, etc) will be used more for severe Raynaud’s phenomenon...now that the Can Rheum Assn is recommending them.

Patients with Raynaud’s have blood vessel spasms that cause painful white, blue, or red fingers and toes...and in severe cases, finger or toe ulcers or gangrene.

Usual triggers are cold exposure and stress. There’s often no underlying medical condition, but it can also be caused by some autoimmune conditions, such as scleroderma and lupus.