Sort Through Options for Managing Heart Failure
December 2025
You’ll hear buzz about finerenone (Kerendia) and the GLP-1 receptor agonists semaglutide and tirzepatide for certain types of heart failure.
There’s some evidence for these in heart failure with mildly reduced ejection fraction (HFmrEF) or preserved EF (HFpEF)...with an EF greater than 40% or 50%, respectively.
And you might hear EF greater than 40% now being called HF with nonreduced ejection fraction (HFnrEF) based on updated Canadian guidelines.
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