Suggest Entresto for heart failure patients with persistent symptoms
You'll hear about Entresto (en-TRESS-toh), a new drug for symptomatic heart failure with reduced ejection fraction.
It's the first "angiotensin receptor neprilysin inhibitor" (ARNI)...and combines sacubitril (sah-KYOO-bih-tril) with valsartan.
Sacubitril works by inhibiting the enzyme neprilysin. This increases vasodilation and urinary sodium loss...and enhances ARB effects.