potentially fatal interaction between colchicine and some macrolides
October 2005
There's concern about a potentially fatal interaction between colchicine and some macrolides.
Erythromycin and clarithromycin (Biaxin) can INCREASE colchicine levels by inhibiting CYP3A4...and also P-glycoprotein.
CYP3A4 metabolizes colchicine to inactive metabolites.
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