Recommend NOT Going Over 100 mg/day of Diclofenac Orally or Rectally
New concerns about cardiovascular safety will lead to lower recommended doses of oral and rectal diclofenac.
We know that diclofenac and other NSAIDs increase the risk of heart attack and stroke. The risk is small, but serious...and differs among the NSAIDs.
Now a new analysis shows that high-dose diclofenac (150 mg/day) increases the risk of cardiovascular events SIMILAR to COX-2 inhibitors such as celecoxib (Celebrex).