Recommend Praxbind to Reverse Life-threatening Bleeding in Patients on Pradaxa

July 2016

Praxbind (PRAKS-bynd, idarucizumab) will be the first agent in Canada to reverse the effects of the anticoagulant, Pradaxa (dabigatran).

We know that vitamin K reverses bleeding due to warfarin...but it doesn't work for Pradaxa and other direct oral anticoagulants (DOACs).

This means that managing bleeding with DOACs has been limited to stopping the drug, using blood products, supportive care, etc.

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Table of Contents

Infectious Diseases Recommend Avoiding Quinolones for Uncomplicated Urinary Tract Infections
Substance Use Disorder Report Suspected Loperamide Misuse to Canada Vigilance
Cardiology Suggest Saving PCSK9 Inhibitors for Patients With Familial Hypercholesterolemia
Chronic Pain Recommend Avoiding Long-Acting Opioids When Starting Pain Treatment
Encourage Prescribers to Write Long-Acting Calcium Channel Blockers Generically
Insomnia Consider Melatonin an Option for Sleep in Elderly Patients
Smoking Cessation Give "Vapers" Resources to Quit E-Cigarettes
Anticoagulants Recommend Praxbind to Reverse Life-threatening Bleeding in Patients on Pradaxa
Anticoagulants Recommend Using Actual Weight to Dose Enoxaparin in Obese Patients
Communication Explain the "Why" to Encourage Patients to Talk Openly
Travel Medicine Tell Travellers Flomax is the Name for an NSAID in Italy